N-Deacetyl Colchiceine

CAS : 3482-37-9

Ref. TR-D198900

Informations sur le produit

• Nom: N-Deacetyl Colchiceine
• Synonymes: Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S)-, Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (S)-, Colchiceine, N-deacetyl- (8CI), Colchicinic acid, O,O',O''-trimethyl- (6CI,7CI), (7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one, Deacetylcolchiceine, Desacetylcolchiceine, N-Deacetylcolchiceine, NSC 36796
• Marque: TRC
• Description: Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Tanaka, H., et al.: Canc. Res., 69, 6978 (2009), D'Elia, M., et al.: Chem. Biol., 16, 548 (2009),

Propriétés chimiques

• Masse moléculaire: 343.37
• Formule: C₁₉H₂₁NO₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1
• Code InChI: InChIKey=IRVWPZRYDQROLU-ZDUSSCGKSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1[C@@H](N)CC2