(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Ammonium Chloride Salt

CAS : 1015073-43-4

Ref. TR-D232075

Informations sur le produit

• Nom: (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Ammonium Chloride Salt
• Synonymes: PSI 7411 Ammonium Chloride Salt

Description

Applications (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Ammonium Chloride Salt is an intermediate in the synthesis of (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Triethylammonium Salt (D235370), an impurity of Sofosbuvir (P839640). Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 393.69
• Formule: C₁₀H₁₄FN₂O₈P•NH₄Cl
• Couleur/Forme: white solid
• InChI: InChI=1S/C10H14FN2O8P.Cl.H4N/c1-10(11)7(15)5(4-20-22(17,18)19)21-8(10)13-3-2-6(14)12-9(13)16;;/h2-3,5,7-8,15H,4H2,1H3,(H,12,14,16)(H2,17,18,19);;1H4/t5-,7-,8-,10?;;/m1../s1
• Code InChI: InChIKey=MALLODSRAQHMHH-VFZAHCDKSA-N