Descyclopropyl Abacavir

CAS : 124752-25-6

Ref. TR-D288865

Informations sur le produit

• Nom: Descyclopropyl Abacavir
• Synonymes: 2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-, Abacavir Related Compound A (USP), Abacavir Sulfate Imp. C (Ph. Int.), Abacavir Sulfate Imp C (EP),2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S,4R)-
• Marque: TRC
• Description: Impurity Abacavir EP Impurity C; Abacavir USP Related Compound AApplications Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Propriétés chimiques

• Masse moléculaire: 246.27
• Formule: C₁₁H₁₄N₆O
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1
• Code InChI: InChIKey=ZKJUXHDSLJYKED-RQJHMYQMSA-N
• SMILES: Nc1nc(N)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1