N-Ethyl Azilsartan Medoxomil

CAS : 1417576-01-2

Ref. TR-D289263

Informations sur le produit

• Nom: N-Ethyl Azilsartan Medoxomil
• Synonymes: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(4-ethyl-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

Description

Applications N-Ethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 596.587
• Formule: C₃₂H₂₈N₄O₈
• Couleur/Forme: Neat
• InChI: InChI=1S/C32H28N4O8/c1-4-35-28(34-44-31(35)38)23-10-7-6-9-22(23)21-15-13-20(14-16-21)17-36-27-24(11-8-12-25(27)33-30(36)40-5-2)29(37)41-18-26-19(3)42-32(39)43-26/h6-16H,4-5,17-18H2,1-3H3
• Code InChI: InChIKey=MKIYPVLTVAXBIW-UHFFFAOYSA-N
• SMILES: CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)n2CC)cc1