(E)-4-(Dimethylamino)but-2-enoyl Chloride-d6

CAS : 1056149-69-9

Ref. TR-D456337

Informations sur le produit

• Nom: (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6
• Synonymes: (E)-4-[bis(trideuteriomethyl)amino]but-2-enoyl chloride

Description

Applications (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6 is an intermediate used in the synthesis of Afatinib-d6 (A355303), which is the d6 labeled analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Schroeder, J., et al.: PCT Int. Appl. WO 2007085638 A1 20070802. Aug 2, 2007;

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 153.64
• Formule: C₆D₆H₄ClNO
• Couleur/Forme: Neat
• InChI: InChI=1S/C6H10ClNO/c1-8(2)5-3-4-6(7)9/h3-4H,5H2,1-2H3/b4-3+/i1D3,2D3
• Code InChI: InChIKey=BOTUQNGRMXZOTH-XDMLVRQJSA-N
• SMILES: [2H]C([2H])([2H])N(C/C=C/C(=O)Cl)C([2H])([2H])[2H]