Ditekiren

CAS : 103336-05-6

Ref. TR-D493685

Informations sur le produit

• Nom: Ditekiren
• Synonymes: 1-[(1,1-Dimethylethoxy)carbonyl]-L-prolyl-L-phenylalanyl-N-methyl-L-histidyl-(2S,4S,5S)-5-amino-4-hydroxy-7-methyl-2-(1-methylethyl)octanoyl-N-(2-pyridinylmethyl)-L-isoleucinamide, [1S-[1R*,2R*,4R*(1R*,2R*)]]- 1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl-L-phenylalanyl-N-[2-hydroxy-5-methyl-1-(2-methylpropyl)-4-[[[2-methyl-1-[[(2-pyridinylmethyl)amino]carbonyl]butyl]amino]carbonyl]hexyl]-Nα-methyl-L-histidinamide, MCMC 6317, U 71038, Ditekiren [USAN:INN], Ditekirene, Ditekirene [INN-French], Ditekirenum, Ditekirenum [INN-Latin], Ditiquireno, Ditiquireno [INN-Spanish], L-Histidinamide, 1-((1,1-dimethylethoxy)carbonyl)-L-prolyl-L-phenylalanyl-N-(2-hydroxy-5-methyl-1-(2-methylpropyl)-4-(((2-methyl-1-(((2-pyridinylmethyl)amino)carbonyl)butyl)amino)carbonyl)hexyl)-N(sup alpha)-methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))-, tert-Butyl (2S)-2-(((alphaS)-alpha-(((1S)-1-(((1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-(((1S,2S)-2-methyl-1-((2-pyridylmethyl)carbamoyl)butyl)carbamoyl)hexyl)carbamoyl)-2-imidazol-4-ylethyl)methylcarbamoyl)phenethyl)carbamoyl)-1-pyrrolidinecarboxylate, L-Histidinamide, 1-((1,1-dimethylethoxy)carbonyl)-L-prolyl-L-phenylalanyl-N-(2-hydroxy-5-methyl-1-(2-methylpropyl)-4-(((2-methyl-1-(((2-pyridinylemthyl)amino)carbonyl)butyl)amino)carbonyl)hexyl)-Nalpha-methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))-, 1-(tert-butoxycarbonyl)-L-prolyl-L-phenylalanyl-N-[(1S,2S,4S)-2-hydroxy-5-methyl-1-(2-methylpropyl)-4-({(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)carbamoyl]butyl}carbamoyl)hexyl]-Nα-methyl-L-histidinamide

Description

Applications Ditekiren, is a potent and specific Renin inhibitor pseudohexapeptide with high metabolic stability.
References Thaisrivongs S., et a;.: J. Med. Chem, 29, 10, 2088 (1986); Adedoyin, A., et al.: Drug Metabolism and Disposition, 21, 184 (1993);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 930.186
• Formule: C₅₀H₇₅N₉O₈
• Couleur/Forme: Neat
• InChI: InChI=1S/C50H75N9O8/c1-11-33(6)43(47(64)53-29-35-20-15-16-22-52-35)57-44(61)37(32(4)5)27-42(60)38(24-31(2)3)55-46(63)41(26-36-28-51-30-54-36)58(10)48(65)39(25-34-18-13-12-14-19-34)56-45(62)40-21-17-23-59(40)49(66)67-50(7,8)9/h12-16,18-20,22,28,30-33,37-43
• Code InChI: InChIKey=SASWSEQJAITMKS-LZIVDOIOSA-N
• SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](CC(C)C)NC(=O)C(Cc1c[nH]cn1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)OC(C)(C)C)C(C)C)C(=O)NCc1ccccn1