Donitriptan Hydrochloride

CAS : 170911-68-9

Ref. TR-D532500

Informations sur le produit

• Nom: Donitriptan Hydrochloride
• Synonymes: 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile;hydrochloride, Donitriptan hydrochloride, F-11356, 4-[4-({[3-(2-aminoethyl)-1H-indol-5-yl]oxy}acetyl)piperazin-1-yl]benzonitrile hydrochloride (1:1)

Description

Applications A novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. An antimigraine agent.
References Pauwels, P., et al.: Biochem. Pharmacol., 46, 535 (1993), Kleven, M., et al.: Eur. J. Pharmacol., 281, 219 (1995), Perez, M., et al.: J. Med. Chem., 38, 3602 (1995), Le Grand, B., et al.: J. Cardiovasc. Pharmacol., 32, 435 (1998),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 439.94
• Formule: C₂₃H₂₅N₅O₂·HCl
• Couleur/Forme: Neat
• InChI: InChI=1S/C23H25N5O2.ClH/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;/h1-6,13,15,26H,7-12,16,24H2;1H
• SMILES: Cl.N#Cc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1