Dutasteride a-Dimer (~90%)

CAS : 1648593-70-7

Ref. TR-D735015

Informations sur le produit

• Nom: Dutasteride a-Dimer (~90%)
• Synonymes: Dutasteride Impurity H,(4aR,6aS,7S,9bS,11aR)-N-(2,5-Bis(trifluoromethyl)phenyl)-1-((4aR,6aS,7R,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carbonyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide

Description

Applications Dutasteride α-Dimer is a dimer impurity of Dutasteride (D735000); a dual inhibitor of 5α-reductase isoenzymes type 1 and 2. Dutasteride is structurally related to Finasteride (F342000) and is used in the treatment of benign prostatic hyperplasia.
References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995); Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999); Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 827.94
• Formule: C₄₆H₅₅F₆N₃O₄
• Degré de pureté: ~90%
• Couleur/Forme: Off-White
• InChI: InChI=1S/C46H55F6N3O4/c1-41-19-16-30-26(27(41)9-11-32(41)39(58)53-34-23-24(45(47,48)49)5-8-31(34)46(50,51)52)7-14-36-44(30,4)22-18-38(57)55(36)40(59)33-12-10-28-25-6-13-35-43(3,21-17-37(56)54-35)29(25)15-20-42(28,33)2/h5,8,17-18,21-23,25-30,32-33,35-36H,6-7,9-16,19-20H2,1-4H3,(H,53,58)(H,54,56)/t25-,26-,27?,28?,29?,30?,32+,33-,35+,36+,41-,42-,43+,44+/m0/s1
• Code InChI: InChIKey=VHEQRKYIOQGSHW-RVLZCPJHSA-N
• SMILES: C[C@]12C=CC(=O)N[C@@H]1CC[C@@H]1C2CC[C@@]2(C)C1CC[C@H]2C(=O)N1C(=O)C=C[C@]2(C)C3CC[C@@]4(C)C(CC[C@H]4C(=O)Nc4cc(C(F)(F)F)ccc4C(F)(F)F)[C@@H]3CC[C@@H]12