5-epi Emtricitabine Carboxylic Acid

Ref. TR-E524985

Informations sur le produit

• Nom: 5-epi Emtricitabine Carboxylic Acid
• Synonymes: (2R,5R)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid

Description

Applications 5-epi Emtricitabine Carboxylic Acid is an impurity of 5-epi Emtricitabine (E524980); an epimer of Emtricitabine (E525000) which is a nucleoside reverse transcriptase inhibitor approved for treatment of HIV-1. Emtricitabine also has antagonistic activity against the hepatitis B virus.
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993); Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006); Smith, K., et al.: AIDS, 23, 1547 (2009)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 261.23
• Formule: C₈H₈FN₃O₄S
• Couleur/Forme: Neat
• InChI: InChI=1S/C8H8FN3O4S/c9-3-1-12(8(15)11-5(3)10)4-2-17-7(16-4)6(13)14/h1,4,7H,2H2,(H,13,14)(H2,10,11,15)/t4-,7-/m1/s1
• Code InChI: InChIKey=GQHACZWRCOKKIZ-CLZZGJSISA-N
• SMILES: Nc1nc(=O)n([C@H]2CS[C@H](C(=O)O)O2)cc1F