Epacadostat

CAS : 1204669-58-8

Ref. TR-E565503

Informations sur le produit

• Nom: Epacadostat
• Synonymes: 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]-, [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide, ICBN 24360, INCB 024360
• CAS: 1204669-58-8

Description

Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).
References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 438.23
• Formule: C₁₁H₁₃BrFN₇O₄S
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)
• Code InChI: InChIKey=NPTIPEQJIDTVKR-STQMWFEESA-N
• SMILES: c1cc2c3c(c1)[C@H]1CCC[C@H]1CN3CCNC2