(11b)-21-(1-Ethoxyethoxy)-11,17-dihydroxy-pregn-4-ene-3,20-dione

CAS : 104661-74-7, 104661-75-8

Ref. TR-E892075

Informations sur le produit

• Nom: (11b)-21-(1-Ethoxyethoxy)-11,17-dihydroxy-pregn-4-ene-3,20-dione
• Synonymes: (8S,9S,10R,11S,13S,14S,17R)-17-(2-(1-ethoxyethoxy)acetyl)-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
• Marque: TRC

Description

Applications (11β)-21-(1-Ethoxyethoxy)-11,17-dihydroxy-pregn-4-ene-3,20-dione is an intermediate in the synthesis of Hydrocortisone-2,2,4,6,6,21,21-d7 (H714617), which is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Propriétés chimiques

• Masse moléculaire: 434.57
• Formule: C₂₅H₃₈O₆
• Couleur/Forme: Neat
• InChI: InChI=1S/C25H38O6/c1-5-30-15(2)31-14-21(28)25(29)11-9-19-18-7-6-16-12-17(26)8-10-23(16,3)22(18)20(27)13-24(19,25)4/h12,15,18-20,22,27,29H,5-11,13-14H2,1-4H3/t15?,18-,19-,20-,22+,23-,24-,25-/m0/s1
• SMILES: Cn1cnc([N+](=O)[O-])c1C(=O)O