Ethyl 6-​(4-​Aminophenyl)​-​1-​(4-methoxyphenyl)​-​7-​oxo-​4,​5,​6,​7-​tetrahydro-​1H-​pyrazolo[3,​4-​c]​pyridine-​3-​carboxylate

CAS : 503615-07-4

Ref. TR-E899803

Informations sur le produit

• Nom: Ethyl 6-​(4-​Aminophenyl)​-​1-​(4-methoxyphenyl)​-​7-​oxo-​4,​5,​6,​7-​tetrahydro-​1H-​pyrazolo[3,​4-​c]​pyridine-​3-​carboxylate
• Synonymes: 1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 6-(4-aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-, ethyl ester, 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester, Apixaban intermediate 3, Ethyl 6-(4-aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Description

Applications Ethyl 6-​(4-​Aminophenyl)​-​1-​(4-methoxyphenyl)​-​7-​oxo-​4,​5,​6,​7-​tetrahydro-​1H-​pyrazolo[3,​4-​c]​pyridine-​3-​carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 406.43
• Formule: C₂₂H₂₂N₄O₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H22N4O4/c1-3-30-22(28)19-18-12-13-25(15-6-4-14(23)5-7-15)21(27)20(18)26(24-19)16-8-10-17(29-2)11-9-16/h4-11H,3,12-13,23H2,1-2H3
• Code InChI: InChIKey=UVAQGQOGOJLALA-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc(N)cc1)C2=O