Fmoc-t-butyl-L-alanine

CAS : 139551-74-9

Ref. TR-F621070

Informations sur le produit

• Nom: Fmoc-t-butyl-L-alanine
• Synonymes: Fmoc-neopentylglycine, (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic Acid, Fmoc-Ala(tBu)-OH, N-(9-Fluorenylmethyloxycarbonyl)-neopentylglycine, N-Alpha-(9-Fluoroenylmethoxycarbonyl)-Beta-T-Butyl-L-Alanine, N-Alpha-(9-Fluoroenylmethoxycarbonyl)-Gamma-Methyl-L-Leucine, N-(9-Fluorenylmethyloxycarbonyl)-Neopentylglycine, N-Alpha-(9-Fluorenylmethoxycarbonyl)-Beta-T-Butyl-L-Alanine, N-Alpha-(9-Fluorenylmethyloxycarbonyl)-L-Neopentylglycine, N-Alpha-(9-Fluorenylmethoxycarbonyl)-Gamma-Methyl-L-Leucine, Fmoc-(Neopentyl)Gly-Oh

Description

Applications Fmoc-t-butyl-L-alanine is used in the synthesis arylaminoethyl amides as noncovalent inhibitors of cathepsin S. It is also an intermediate used to prepare oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
References Liu, H., et al.: Bioorg. Med. Chem. Lett., 15, 4979 (2005); Linton, S., et al.: Bioorg. Med. Chem. Lett., 14, 2685 (2004)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 367.44
• Formule: C₂₂H₂₅NO₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H25NO4/c1-22(2,3)12-19(20(24)25)23-21(26)27-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
• Code InChI: InChIKey=RPLVCXKSSXJFDS-IBGZPJMESA-N
• SMILES: CC(C)(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O