Fosaprepitant-d4 Dimeglumine

CAS : 265121-04-8

Ref. TR-F727307

Informations sur le produit

• Nom: Fosaprepitant-d4 Dimeglumine
• Synonymes: [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate 1-Deoxy-1-(methylamino)-D-glucitol, MK 0517-d4
• Marque: TRC
• Description: Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Propriétés chimiques

• Masse moléculaire: 1008.86
• Formule: C₃₇H₅₂D₄F₇N₆O₁₆P
• Couleur/Forme: Neat
• InChI: InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);2*4-13H,2-3H2,1H3/t12?,19-,20+;2*4-,5+,6+,7+/m000/s1/i2D,3D,4D,5D
• Code InChI: InChIKey=UGJUJYSRBQWCEK-KQNYYRRBSA-N
• SMILES: CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[2H]c1c([2H])c([C@H]2[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OCCN2Cc2nn(P(=O)(O)O)c(=O)[nH]2)c([2H])c([2H])c1F