GSK 923295

CAS : 1088965-37-0

Ref. TR-G797750

Informations sur le produit

• Nom: GSK 923295
• Synonymes: 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide, GSK 923295A
• CAS: 1088965-37-0

Description

Applications GSK 923295 is the first potent, CENP-E-selective inhibitor that has been tested in Phase I clinical trials for treatment of Refractory Cancers.
References Wood, K., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 5839 (2010); Qian, X., et al.: ACS Med. Chem. Lett., 1, 30 (2010); Lock, R., et al. Pediatr. Blood Cancer, 58, 916 (2012); Mayes, P., et al.: Int. J. Cancer, 132, E149 (2013)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 592.13
• Formule: C₃₂H₃₈ClN₅O₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
• Code InChI: InChIKey=WHMXDBPHBVLYRC-OFVILXPXSA-N
• SMILES: CC(C)Oc1ccc(C(=O)N[C@H](CNC(=O)CN(C)C)Cc2ccc(-c3cn4cccc([C@H](C)O)c4n3)cc2)cc1Cl