4-Hydroxy-7-methoxy-6-quinolinecarboxamide

CAS : 2110414-05-4

Ref. TR-H211040

Informations sur le produit

• Nom: 4-Hydroxy-7-methoxy-6-quinolinecarboxamide
• Synonymes: 4-hydroxy-7-methoxyquinoline-6-carboxamide

Description

Applications 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​ is useful in the synthetic preparation of Lenvatinib (L329400(P)) with high purity. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Liu, S., et al.: Faming Zhuanli Shenqing (2020), CN 111377865 A; Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 218.209
• Formule: C₁₁H₁₀N₂O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H10N2O3/c1-16-10-5-8-6(4-7(10)11(12)15)9(14)2-3-13-8/h2-5H,1H3,(H2,12,15)(H,13,14)
• Code InChI: InChIKey=ZXSGIBJYMYHCMM-UHFFFAOYSA-N
• SMILES: COc1cc2nccc(O)c2cc1C(N)=O