2-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

CAS : 144875-91-2

Ref. TR-H448750

Informations sur le produit

• Nom: 2-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

Description

Applications 2-(Hydroxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol is an intermediate in the synthesis of O-deethylated Resiquimod (D228575), which is derived from its parent compound Resiquimod (R144680), which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 271.31
• Formule: C₁₅H₁₇N₃O₂
• Couleur/Forme: Pale Solid
• InChI: InChI=1S/C15H17N3O2/c1-15(2,20)9-18-13(8-19)17-12-7-16-11-6-4-3-5-10(11)14(12)18/h3-7,19-20H,8-9H2,1-2H3
• Code InChI: InChIKey=ZCIGSNPPLVNKQF-UHFFFAOYSA-N
• SMILES: CC(C)(O)Cn1c(CO)nc2cnc3ccccc3c21