Hydrocortisone 17-Propionate 21-Acetate

CAS : 74050-20-7

Ref. TR-H714628

Informations sur le produit

• Nom: Hydrocortisone 17-Propionate 21-Acetate
• Synonymes: Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11ß)-, (11ß)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione, Cortisol 17-propionate 21-acetate, Hydrocortisone aceponate, Retef, (11Beta)-21-(Acetyloxy)-11-Hydroxy-3,20-Dioxopregn-4-En-17-Yl Propanoate, (11β)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione, 11beta,17,21-Trihydroxy pregn-4-ene-3,20-dione 21-acetate 17-propionate, Aceponate d'hydrocortisone, Aceponate d'hydrocortisone [French], Aceponato de hidrocortisona, Aceponato de hidrocortisona [Spanish], Cortacare, Cortavance, Efficort, Hydrocortisone 17-propionate 21-acetate, Hydrocortisone-17-aceponate, Hydrocortisoni aceponas, Hydrocortisoni aceponas [Latin], Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11β)-, Suniderma, Unii-2340Up1L2G

Description

Applications A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid.
References Dooms-Goossens, A., et al.: Eur. J. Dermatol., 3, 713 (1993), Isaksson, M., et al.: Contact Dermatitis, 43, 41 (2000), Matura, M., et al.: Allergy, 55, 698 (2000),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 460.56
• Formule: C₂₆H₃₆O₇
• Couleur/Forme: White To Beige
• InChI: InChI=1S/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
• Code InChI: InChIKey=MFBMYAOAMQLLPK-FZNHGJLXSA-N
• SMILES: CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C