2-Hydroxy Estradiol 6-N3-Adenine

CAS : 912671-55-7

Ref. TR-H942160

Informations sur le produit

• Nom: 2-Hydroxy Estradiol 6-N3-Adenine
• Synonymes: (17ß)-6-(6-Amino-3H-purin-3-yl)-estra-1,3,5(10)-triene-2,3,17-triol

Description

Applications 2-Hydroxy Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 421.49
• Formule: C₂₃H₂₇N₅O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C23H27N5O3/c1-23-5-4-11-12-7-17(29)18(30)8-14(12)16(6-13(11)15(23)2-3-19(23)31)28-10-27-21(24)20-22(28)26-9-25-20/h7-11,13,15-16,19,29-31H,2-6,24H2,1H3/t11-,13-,15+,16?,19+,23+/m1/s1
• Code InChI: InChIKey=SKTXDUKLUKAABT-MIPWJFNXSA-N
• SMILES: C[C@]12CC[C@@H]3c4cc(O)c(O)cc4C(n4cnc(N)c5ncnc4-5)C[C@H]3[C@@H]1CC[C@@H]2O