Iso Desloratadine

CAS : 183198-49-4

Ref. TR-I814995

Informations sur le produit

• Nom: Iso Desloratadine
• Synonymes: 8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (11RS)-8-chloro-11-(1,2,3,6-tetrahydropyridin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Desloratadine Imp. B (EP), 8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Description

Impurity Desloratadine EP Impurity B
Stability Hygroscopic, Light Sensitive
Applications Iso Desloratadine (Desloratadine EP Impurity B) is an impurity of Desloratadine (D290250), which is a nonsedating-type histamine H1-receptor antagonist. Desloratadine is an active metabolite of Loratadine (L469575). Also inhibits generation and release of inflammatory mediators from basophils and mast cells. An impurity arising in the synthesis of Rupatadine (R701650).
References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000); Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000); Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 310.82
• Formule: C₁₉H₁₉ClN₂
• Couleur/Forme: Off-White
• InChI: InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-7,9,12,18,21H,3-4,8,10-11H2
• Code InChI: InChIKey=ADSCCBORDDPTRQ-UHFFFAOYSA-N
• SMILES: Clc1ccc2c(c1)CCc1cccnc1C2C1=CCNCC1