3α-Hydroxy-7-oxocholanoyltaurine

CAS : 75808-01-4

Ref. TR-K175030

Informations sur le produit

• Nom: 3α-Hydroxy-7-oxocholanoyltaurine
• Synonymes: 2-[[(4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid, 7-Oxolithocholic acid-taurine conjugate, 7-Ketolithocholic acid-taurine conjugate, Ethanesulfonic acid, 2-[[(3α,5β)-3-hydroxy-7,24-dioxocholan-24-yl]amino]-, 2-[[(3α,5β)-3-Hydroxy-7,24-dioxocholan-24-yl]amino]ethanesulfonic acid

Description

Applications 7-Ketolithocholic Acid-taurine Conjugate is a bile acid conjugate and metabolite of Taurolithocholic Acid (T009100) with antiinflammatory activity. Taurochenodeoxycholic Acid has been shown to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria.
References Emerman, S. et al.: J. Biol. Chem., 242, 661 (1967); Takikawa, Y. et al.: Falk Symp., 120, 249 (2001); Li, P. et al.: Zhong. Shour. Xue., 28, 1317 (2008);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 497.688
• Formule: C₂₆H₄₃NO₆S
• Couleur/Forme: Neat
• InChI: InChI=1S/C26H43NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-21,24,28H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,24+,25+,26-/m1/s1
• Code InChI: InChIKey=QNRIYEYAHVEGQJ-SWQVIYSDSA-N
• SMILES: C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C