Lopinavir O-Beta-D-Glucuronide

Ref. TR-L469535

Informations sur le produit

• Nom: Lopinavir O-Beta-D-Glucuronide
• Synonymes: (2S,3S,5R,6R)-6-(((2S,3S,5S)-2-(2-(2,6-Dimethylphenoxy)acetamido)-5-((S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamido)-1,6-diphenylhexan-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid

Description

Applications Lopinavir O-β-D-Glucuronide is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product.
References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 804.92
• Formule: C₄₃H₅₆N₄O₁₁
• Couleur/Forme: Neat
• InChI: InChI=1S/C43H56N4O11/c1-25(2)34(47-20-12-19-44-43(47)55)40(52)45-30(21-28-15-7-5-8-16-28)23-32(57-42-37(51)35(49)36(50)39(58-42)41(53)54)31(22-29-17-9-6-10-18-29)46-33(48)24-56-38-26(3)13-11-14-27(38)4/h5-11,13-18,25,30-32,34-37,39,42,49-51H,12,19-24H2,1-4H3,(H,44,55)(H,45,52)(H,46,48)(H,53,54)/t30-,31-,32-,34-,35+,36+,37-,39+,42-/m0/s1
• Code InChI: InChIKey=JHHFXCLZVWIVJA-WJDOUJDHSA-N
• SMILES: Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O)O[C@H]1O[C@@H](C(=O)O)[C@H](O)[C@@H](O)[C@@H]1O