Mafosfamide Sodium Salt

CAS : 84211-05-2

Ref. TR-M110300

Informations sur le produit

• Nom: Mafosfamide Sodium Salt
• Synonymes: rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium, Mafosfamid Sodium, Z 7557, cis-Mafosfamide Sodium

Description

Stability Moisture Sensitive, Very Hygroscopic
Applications A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent.
References Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999), Lips, J., et al.: Carcinogenesis, 22, 579 (2001), Ward, I., et al.: J. Biol. Chem., 276, 47759 (2001), Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (2003), Roos, W., et al.: Oncogene, 26, 186 (2007),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 423.24
• Formule: C₉H₁₈Cl₂N₂NaO₅PS₂
• Couleur/Forme: White To Light Beige
• InChI: InChI=1S/C9H19Cl2N2O5PS2.Na/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17;/h9H,1-8H2,(H,12,14)(H,15,16,17);/q;+1/p-1/t9-,19-;/m1./s1
• Code InChI: InChIKey=PBUUPFTVAPUWDE-UHFFFAOYSA-N
• SMILES: O=P1(N(CCCl)CCCl)NC(SCCS(=O)(=O)O)CCO1