Mesna

CAS : 19767-45-4

Ref. TR-M225750

Informations sur le produit

• Nom: Mesna
• Synonymes: Sodium 2-sulfanylethanesulfonate, Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1) (ACI), Ethanesulfonic acid, 2-mercapto-, monosodium salt (8CI, 9CI), 2-Mercapto-1-ethanesulfonic acid monosodium salt, 2-Mercaptoethanesulfonic acid monosodium salt, 2-Mercaptoethanesulfonic acid sodium salt, D 7093, MeSH ID: D015080, Mesnex, Mesnum, Mistabron, Mistabronco, Mitexan, Mucofluid, Prehepon, Sodium 2-mercaptoethanesulfonate, UCB 3983
• Marque: TRC

Description

Applications Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
References Tekeres, M., et al.: Clin. Ther., 4, 56 (1981), Brock, N., et al.: Eur. J. Cancer Clin Oncol., 18, 1377 (1982), James, C.A., et al.: Br. J. Clin. Pharmacol., 23, 561 (1987), Schoenike, S.E., et al.: Clin. Pharm., 9, 179 (1990),

Propriétés chimiques

• Masse moléculaire: 164.18
• Formule: C₂H₅O₃S₂·Na
• Couleur/Forme: Neat
• InChI: InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
• SMILES: O=S(=O)([O-])CCS.[Na+]