L-Methionine [R,S]-Sulfoximine-13C5

CAS : 15985-39-4

Ref. TR-M260502

Informations sur le produit

• Nom: L-Methionine [R,S]-Sulfoximine-13C5
• Synonymes: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine-13C5, (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid-13C5
• Marque: TRC

Description

Applications L-Methionine [R,S]-Sulfoximine-13C5,15N is the isotope labelled analog of L-Methionine [R,S]-Sulfoximine. Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.
References Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)

Propriétés chimiques

• Masse moléculaire: 185.19
• Formule: C₅H₁₂N₂O₃S
• Couleur/Forme: Neat
• InChI: InChI=1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1/i1+1,2+1,3+1,4+1,5+1
• Code InChI: InChIKey=SXTAYKAGBXMACB-GLBMLLDXSA-N
• SMILES: [13CH3]S(=N)(=O)[13CH2][13CH2][13C@H](N)[13C](=O)O