N-(4-methylbenzenesulfonamide) Tolafentrine

Ref. TR-M289790

Informations sur le produit

• Nom: N-(4-methylbenzenesulfonamide) Tolafentrine
• Synonymes: N-(4-((4aS,10bR)-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)phenyl)-4-methyl-N-tosylbenzenesulfonamide

Description

Applications N-(4-methylbenzenesulfonamide) Tolafentrine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
References Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 659.815
• Formule: C₃₅H₃₇N₃O₆S₂
• Couleur/Forme: Light Yellow Solid
• InChI: InChI=1S/C35H37N3O6S2/c1-23-6-14-27(15-7-23)45(39,40)38(46(41,42)28-16-8-24(2)9-17-28)26-12-10-25(11-13-26)35-30-21-34(44-5)33(43-4)20-29(30)31-22-37(3)19-18-32(31)36-35/h6-17,20-21,31-32H,18-19,22H2,1-5H3/t31-,32-/m0/s1
• Code InChI: InChIKey=PZERWNOCNZEZJV-ACHIHNKUSA-N
• SMILES: COc1cc2c(cc1OC)[C@@H]1CN(C)CC[C@@H]1N=C2c1ccc(N(S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c2ccc(C)cc2)cc1