(11,12,12,6α-Methyl-D6)-Prednisolone

CAS : 83-43-2

Ref. TR-M327232

Informations sur le produit

• Nom: (11,12,12,6α-Methyl-D6)-Prednisolone
• Synonymes: (6S,8S,9S,10R,11S,13S,14S,17R)-11,12,12-trideuterio-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6-(trideuteriomethyl)-7,8,9,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one, (6Alpha,11Beta)-11,17,21-Trihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione, (6Alpha,8Xi,9Xi,11Beta,14Xi)-11,17,21-Trihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione, (6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione, 11,17,21-Trihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione, 11-Beta,17-Alpha,21-Trihydroxy-6-Alpha-Methylpregna-1,4-Diene-3,20-Dione, 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione, 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6-α-Methylprednisolone, 6alpha-Methyl Prednisolone, 6α-Methyl-11β,17α,21β-trihydroxy-1,4-pregnadiene-3,20-dione, 6α-Methylprednisolone, A-Methapred, Besonia, Dopomedrol, Duralone, M-Prednisol, Medesone, Medorol, Medralone, Medrate, Medrol, Medrone, Metastab, Methyl prednisolone, Methylprednisolon, Methylprednisolone, Methypred, Metilbetasone, Metilprednisolona, Metilprednisolone, Metipred, Metrisone, Moderin, Noretona, Nsc 19987, Prednol, Prednol L, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6α,11β)-, Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, Promacortine, Solimedrol, Suprametil, Sw 196788, U 7532, Urbason, Urbasone, Urbazone, Wyacort, Δ1-6α-Methylhydrocortisone, Δ¹-6α-Methylhydrocortisone

Description

Applications (11,12,12,6α-Methyl-D6)-Prednisolone is the labeled analogue of 6α-Methyl Prednisolone (M325934), a glucocorticoid which displays anti-inflamatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective.
References Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992); Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996); Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998); Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 380.508
• Formule: C₂₂D₆H₂₄O₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1/i1D3,10D2,17D
• Code InChI: InChIKey=VHRSUDSXCMQTMA-WUDTYJIMSA-N
• SMILES: [2H]C([2H])([2H])[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C([2H])([2H])[C@]([2H])(O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12