(AlphaR)-2-Fluoro-Alpha-methyl[1,1'-biphenyl]-4-acetate (AlphaS)-Alpha-Methylbenzenemethanamine

CAS : 76319-53-4

Ref. TR-M763195

Informations sur le produit

• Nom: (AlphaR)-2-Fluoro-Alpha-methyl[1,1'-biphenyl]-4-acetate (AlphaS)-Alpha-Methylbenzenemethanamine

Description

Applications (αR)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetate (αS)-α-Methylbenzenemethanamine is an intermediate in the synthesis of Rimacalib (R505015), an inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib.
References Westra, Johanna., et al.: BMC Musculoskelet Disord.,11 , No pp. given. (2010);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 244.26 + 121.18
• Formule: C₁₅H₁₃FO₂•C₈H₁₁N
• InChI: InChI=1S/C15H13FO2.C8H11N/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11;1-7(9)8-5-3-2-4-6-8/h2-10H,1H3,(H,17,18);2-7H,9H2,1H3/t10-;7-/m10/s1
• Code InChI: InChIKey=SXXYXEUZKYVLQA-JIJBYVMQSA-N
• SMILES: C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1.C[C@H](N)c1ccccc1