β-Nicotinamide Mononucleotide

CAS : 1094-61-7

Ref. TR-N407765

Informations sur le produit

• Nom: β-Nicotinamide Mononucleotide
• Synonymes: Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt, 3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide, 5'-phosphate, inner salt (6CI,7CI), Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, hydroxide, inner salt, Pyridinium, 3-carbamoyl-1-β-D-ribofuranosyl-, hydroxide, 5'-(dihydrogen phosphate), inner salt (8CI), NMN, NMN (mononucleotide), Nicotinamide mononucleotide, Nicotinamide ribonucleoside 5'-phosphate, Nicotinamide ribonucleotide, Nicotinamide ribotide, β-D-NMN, β-NMN
• Marque: TRC
• Description: Stability Very HygroscopicApplications A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009)

Propriétés chimiques

• Masse moléculaire: 334.22
• Formule: C₁₁H₁₅N₂O₈P
• Couleur/Forme: White
• InChI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
• SMILES: N=C(O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]2O)c1