β-Nicotinamide Mononucleotide-13C5

CAS : 1094-61-7

Ref. TR-N407767

Informations sur le produit

• Nom: β-Nicotinamide Mononucleotide-13C5
• Synonymes: [(2R,3R,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy(2,3,4,5-13C4)oxolan-2-yl](113C)methyl hydrogen phosphate, 3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium, 3-Carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt, 3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium, 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium, NMN, NMN (mononucleotide), Nicotinamide mononucleotide, Nicotinamide ribonucleoside 5′-phosphate, Nicotinamide ribonucleotide, Nicotinamide ribotide, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, hydroxide, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, inner salt, Pyridinium, 3-carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt, coenzyme NMN, β-<span class="text-smallcaps">D</span>-NMN, β-NMN, β-Nicotinamide mononucleotide

Description

Applications The labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 339.182
• Formule: C₅C₆H₁₅N₂O₈P
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8+,9-,11-/m1/s1/i5+1,7+1,8+1,9+1,11+1
• SMILES: NC(=O)c1ccc[n+]([13C@@H]2O[13C@H]([13CH2]OP(=O)([O-])O)[13C@H](O)[13C@H]2O)c1