S-(4-Nitrobenzyl)-6-thioinosine

CAS : 38048-32-7

Ref. TR-N493695

Informations sur le produit

• Nom: S-(4-Nitrobenzyl)-6-thioinosine
• Synonymes: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine, S-(p-Nitrobenzyl)-6-mercapto
• CAS: 38048-32-7

Description

Applications S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
References (1) Zhu, Z., et al.: J. Med. Chem., 46, 831 (2003) (2) Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (2005) (3) Barnes, K., et al.: Circ. Res., 99, 510 (2006)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 419.41
• Formule: C₁₇H₁₇N₅O₆S
• Couleur/Forme: White to Off-White Solid
• InChI: InChI=1S/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1
• SMILES: O=[N+]([O-])c1ccc(CSc2ncnc3c2ncn3[C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)cc1