NU6027

CAS : 220036-08-8

Ref. TR-N925280

Informations sur le produit

• Nom: NU6027
• Synonymes: 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine, Nu6027

Description

Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors
References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 251.285
• Formule: C₁₁H₁₇N₅O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
• Code InChI: InChIKey=DGWXOLHKVGDQLN-UHFFFAOYSA-N
• SMILES: Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1