Paclitaxel

CAS : 33069-62-4

Ref. TR-P132500

Informations sur le produit

• Nom: Paclitaxel
• Synonymes: 5beta,20-Epoxy-1,7beta-dihydroxy-9-oxotax-11-ene-2alpha,4,10beta,13alpha-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate], Taxol, Docetaxel Anhydrous Impurity F, Docetaxel Impurity F, 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv., 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv., Abi 007, Abraxane, Anzatax, Apealea, Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-, Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-, Bms 181339-01, Capxol, Coroflex Please, Cremophor-free paclitaxel, Cyclopax, Cynviloq, Cypher select, Dhp 107, Ebetaxel, EmPAC, EndoTAG 1, Genaxol, Genetaxyl, Genexol, Genexol-PM, Ig 001, Ig 002, Infinnium, Intaxel, Lep-Etu, Liposome-entrapped paclitaxel easy-to-use, Mbt 0206, Mitotax, Nab-paclitaxel, Nanotax, Nanoxel, Nk 105, Nsc 125973, OncoGel, Onxal, Oraxol, Pacitaxel, Pacliex, Padexol, Paxene, Pazenir, Plaxicel, Qw 8184, Sindaxel, TAXUS Express, TAXUS stent, Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, TaxAlbin, Taxal, Taxol A, Taxus, Taxus Liberte, Tocosol Paclitaxel, Yewtaxan

Description

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 853.91
• Formule: C₄₇H₅₁NO₁₄
• Couleur/Forme: Off-White
• InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
• Code InChI: InChIKey=RCINICONZNJXQF-NQCIZAMRSA-N
• SMILES: CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)CC3OCC3(OC(C)=O)[C@H]2[C@@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C