Panobinostat-d8 (Major) Hydrochloride Salt

CAS : 1185237-51-7 404950-80-7

Ref. TR-P180502

Informations sur le produit

• Nom: Panobinostat-d8 (Major) Hydrochloride Salt
• Synonymes: (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl-d8)ethyl]amino]methyl]phenyl]-2-propenamide Hydrochloride, LBH 589-d8 Hydrochloride
• CAS: 1185237-51-7 404950-80-7

Description

Applications The novel labelled histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
References Claus, R., et al.: Oncogene, 22, 6489 (2003), Johnstone, R., et al.: Cancer Cell., 4, 13 (2003), Ying, J., et al.: Clin. Cancer Res., 11, 6442 (2005), Catley, L., et al.: Blood, 108, 3441 (2006), Steinberg, M., et al.: Clin. Ther., 29, 2289 (2007),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 393.94
• Formule: C₂₁H₁₆D₈ClN₃O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C21H23N3O2.ClH/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26;/h2-11,22-23,26H,12-14H2,1H3,(H,24,25);1H/b11-10+;/i1D3,2D,3D,4D,5D,14D
• Code InChI: InChIKey=UPWMDRRETYJAKD-VHSANZFESA-N
• SMILES: Cl.[2H]c1c([2H])c([2H])c2c(CCNC([2H])c3ccc(/C=C/C(=O)NO)cc3)c(C([2H])([2H])[2H])[nH]c2c1[2H]