PD-161570

CAS : 192705-80-9

Ref. TR-P217490

Informations sur le produit

• Nom: PD-161570
• Synonymes: 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea, Urea, N-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)-, 1-tert-Butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea, PD 161570, N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea

Description

Applications PD-161570 is a novel FGF-1 receptor tyrosine kinase inhibitor, which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells (1,2,3).
References (1) Nandi, S. et al.: J. Enz. Inhib. Med. Chem., 24, 937 (2009)(2) Batley, B. L. et al.: Life Sci., 62, 143 (1998) (3) Hamby, J.M. et al.: J. Med. Chem., 40, 2296 (1997)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 532.51
• Formule: C₂₆H₃₅Cl₂N₇O
• Couleur/Forme: Neat
• InChI: InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)
• Code InChI: InChIKey=MKVMEJKNLUWFSQ-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(NC(=O)NC(C)(C)C)nc2n1