PF 431396

CAS : 717906-29-1

Ref. TR-P218290

Informations sur le produit

• Nom: PF 431396
• Synonymes: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide, N-Methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]phenyl}methanesulfonamide

Description

Applications PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Han, et al.: J. Biol. Chem., 284 13193 (2009), Allen, et al.: J. Med. Chem., 53 4332 (2010),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 506.5
• Formule: C₂₂H₂₁F₃N₆O₃S
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30)
• Code InChI: InChIKey=POJZIZBONPAWIV-UHFFFAOYSA-N
• SMILES: CN(c1ccccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O