PF 3845

CAS : 1196109-52-0

Ref. TR-P293760

Informations sur le produit

• Nom: PF 3845
• Synonymes: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, 1-Piperidinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-, Pf-3845, N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide

Description

Applications PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ahn, et al.: Chem. Biol., 16, 411 (2009), Ahn, et al.: Expert. Opin. Drug Discov., 4 763 (2009),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 456.46
• Formule: C₂₄H₂₃F₃N₄O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C24H23F3N4O2/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,30,32)
• Code InChI: InChIKey=NBOJHRYUGLRASX-UHFFFAOYSA-N
• SMILES: O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cn3)c2)CC1