Piperaquine-d6 Tetraphosphate

CAS : 1261394-71-1

Ref. TR-P480052

Informations sur le produit

• Nom: Piperaquine-d6 Tetraphosphate
• Synonymes: 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis[7-chloroquinoline]-d6 Tetraphosphate

Description

Applications Piperaquine-d6, is a 4-aminoquinoline derivative used as an antimalarial agent. Piperaquine interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It is commonly used in combination with Dihydroartemisinin (D448360) for the treatment of multi-drug resistant falciparum malaria.
References Nguyen, T.M.T. et al.: Tap Chi Duoc Hoc, 57, 22 (2007); Song, J. et al.: Malaria J., 10, 231 (2011);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 933.53
• Formule: C₂₉H₂₆D₆Cl₂N₆•4H₃PO₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C29H32Cl2N6.4H3O4P/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;4*1-5(2,3)4/h2-9,20-21H,1,10-19H2;4*(H3,1,2,3,4)/i1D2,10D2,11D2
• Code InChI: InChIKey=OAKKJVUSSVZQRF-RWWSHYHISA-N
• SMILES: O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O.[2H]C([2H])(N1CCN(c2ccnc3cc(Cl)ccc23)CC1)C([2H])([2H])C([2H])([2H])N1CCN(c2ccnc3cc(Cl)ccc23)CC1