Pyrimethamine

CAS : 58-14-0

Ref. TR-P997240

Informations sur le produit

• Nom: Pyrimethamine
• Synonymes: 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine, 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine, 2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine, 4753 R.P., 5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine, 5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, BW 50-63, Chloridin, Chloridine, Darachlor, Darapram, Daraprim, Daraprime, Diaminopyritamin, Erbaprelina, Khloridin, Malacid, Malocid, Malocide, NSC 3061, Pirimecidan, Pirimetamin, Pyrimethamin, RP 4753, Tindurin, Tinduring, WR 2978, 2, 4-Diamino-5-(4'-chlorophenyl)-6-ethylpyrimidine, 2, 4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine, 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, Bw 50-63, Nsc 3061, Pirimetamina, Pyrimethamine Base, Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-, Rp 4753, Wr 2978

Description

Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 248.71
• Formule: C₁₂H₁₃ClN₄
• Couleur/Forme: White Solid
• InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
• Code InChI: InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N
• SMILES: CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1