R406

CAS : 841290-81-1

Ref. TR-R060000

Informations sur le produit

• Nom: R406
• Synonymes: 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one Monobenzenesulfonate
• Marque: TRC

Description

Applications R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).
References Borge, M. et al.: J. Immunol., 193, 3165 (2014); Kimura, Y. et al.: J. Biol. Chem., 289, 31565 (2014);

Propriétés chimiques

• Masse moléculaire: 628.6
• Formule: C₂₂H₂₃FN₆O₅·(C₆H₆O₃S)
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H23FN6O5.C6H6O3S/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4;7-10(8,9)6-4-2-1-3-5-6/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30);1-5H,(H,7,8,9)
• Code InChI: InChIKey=UXDRJPYSTZHIOE-UHFFFAOYSA-N
• SMILES: COc1cc(Nc2ncc(F)c(N=c3ccc4c([nH]3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC.O=S(=O)(O)c1ccccc1