Regorafenib N-β-D-Glucuronide Sodium Salt

CAS : 755037-03-7

Ref. TR-R143320

Informations sur le produit

• Nom: Regorafenib N-β-D-Glucuronide Sodium Salt
• Synonymes: (2S,3S,4S,5R,6R)-6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid Sodium Salt
• Marque: TRC
• Description: Applications Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Propriétés chimiques

• Masse moléculaire: 680.92
• Formule: C₂₇H₂₂ClF₄N₄O₉·Na
• Couleur/Forme: Neat
• InChI: InChI=1S/C27H23ClF4N4O9.Na/c1-33-23(40)18-10-13(6-7-34-18)44-12-3-5-17(16(29)9-12)35-26(43)36(11-2-4-15(28)14(8-11)27(30,31)32)24-21(39)19(37)20(38)22(45-24)25(41)42;/h2-10,19-22,24,37-39H,1H3,(H,33,40)(H,35,43)(H,41,42);/q;+1/p-1/t19-,20-,21+,22-,24+;/m0./s1
• Code InChI: InChIKey=AWDORCFLUJZUQS-CYBMUJFWSA-N
• SMILES: Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@H]3C)c12