Retorphan

CAS : 112573-72-5

Ref. TR-R278500

Informations sur le produit

• Nom: Retorphan
• Synonymes: benzyl 2-[[(2R)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate, Dexecadotril [INN], (+)-N-((R)-alpha-(Mercaptomethyl)hydrocinnamoyl)glycine, benzyl ester, acetate (ester), (R)-Acetorphan, (R)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester, N-(2-Acetylthiomethyl-1-oxo-3-phenylpropyl)glycine-R(+)-benzyl ester, Unii-5Ofi9D9892, Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (R)-, benzyl N-[(2R)-3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate

Description

Applications Retorphan is a powerful and selective inhibitors of neprilysin and is being developed as a therapeutic agent. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).
References Monteil, T., et al.: Mini. Rev. Med. Chem., 2, 209 (2002); Roques, B.P., et al.: Nature, 288, 286 (1980); Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 385.48
• Formule: C₂₁H₂₃NO₄S
• Couleur/Forme: Neat
• InChI: InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/t19-/m0/s1
• Code InChI: InChIKey=RQUVSNGNEJMOBE-VTFQDDHLSA-N
• SMILES: C=CCOc1nc2c(=O)[nH]c(N)nc2n1[C@@H]1O[C@H](CO)C(O)C1O