Roxadustat Methyl Ester

CAS : 1421312-36-8

Ref. TR-R410460

Informations sur le produit

• Nom: Roxadustat Methyl Ester
• Synonymes: methyl 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetate

Description

Applications Roxadustat Methyl Ester is used in the preparation of Roxadustat.Roxadustat (H948180) is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.It is used for treatment of anemia in patient with chronic kidney disease.
References Wang, Z.: Faming Zhuanli Shenqing. 7 pp. (2018)Provenzano, R., et al.: J. Clin. Pharmacol. 60, 1432 (2020)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 366.367
• Formule: C₂₀H₁₈N₂O₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C20H18N2O5/c1-12-16-10-14(27-13-6-4-3-5-7-13)8-9-15(16)19(24)18(22-12)20(25)21-11-17(23)26-2/h3-10,24H,11H2,1-2H3,(H,21,25)
• Code InChI: InChIKey=QSGJZCCNTOCDRI-UHFFFAOYSA-N
• SMILES: COC(=O)CNC(=O)c1nc(C)c2cc(Oc3ccccc3)ccc2c1O