Selumetinib

CAS : 606143-52-6

Ref. TR-S254000

Informations sur le produit

• Nom: Selumetinib
• Synonymes: 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide, 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-, 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester, 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, 6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide, Arry-142886, Azd 6244, Azd-6224, Azd6244, G 00039805, Koselugo, NSC 741O78, Zd-6244

Description

Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. It is useful as biomarker in human lung cancer cell. Potent MEK inhibitor.
References Ciardiello, F., et al.: Clin. Cancer Res., 7, 1459 (2001), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 457.68
• Formule: C₁₇H₁₅BrClFN₄O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
• Code InChI: InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N
• SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21