Tiazofurin

CAS : 60084-10-8

Ref. TR-T437200

Informations sur le produit

• Nom: Tiazofurin
• Synonymes: 4-Thiazolecarboxamide, 2-ß-D-ribofuranosyl-, 2-ß-D-Ribofuranosyl-4-thiazolecarboxamide, 2-ß-D-Ribofuranosylthiazole-4-carboxamide, CI 909, NSC 286-193, NSC 286193, Riboxamide, TCAR, Tiazofurine, (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol, 1,4-Anhydro-1-(4-Carbamoyl-1,3-Thiazol-2-Yl)Pentitol, 2-beta-D-Ribofuranosyl-4-thiazolecarboxamide, 2-beta-D-Ribofuranosylthiazole-4-carboxamide, 2-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-4-thiazolecarboxamide, 2-β-<span class="text-smallcaps">D</span>-Ribofuranosylthiazole-4-carboxamide, 4-Thiazolecarboxamide, 2-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, Ci 909, 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl-, 2-β-D-Ribofuranosyl-4-thiazolecarboxamide, 2-β-D-Ribofuranosylthiazole-4-carboxamide

Description

Stability Very Very Hygroscopic
Applications Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.
References Streeter, D.G. et al.: Biochem. Biophys. Res. Comm., 115, 544 (1983); Boritzki, T. et al.: Biochem. Pharmacol., 34, 1109 (1985); Malek, K. et al.: Leuk. Res., 28, 1125 (2004);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 260.27
• Formule: C₉H₁₂N₂O₅S
• Couleur/Forme: Neat
• InChI: InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1
• Code InChI: InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N
• SMILES: NC(=O)c1csc([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1