TNP-470

CAS : 129298-91-5

Ref. TR-T470000

Informations sur le produit

• Nom: TNP-470
• Synonymes: (Chloroacetyl)-carbamic Acid (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester, [3R-[3α,4α(2R*,3R*),5β,6β]]-(Chloroacetyl)-carbamic Acid 5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester, AGM 1470, Lodamin, NSC 642492, O-Chloroacetylcarbamoylfumagillol
• Marque: TRC
• Description: Applications TNP-470 is a synthetic analog of Fumagillin (F862650); a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis and shows promise as both an anti-infective and antiangiogenic agent.References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990)

Propriétés chimiques

• Masse moléculaire: 401.88
• Formule: C₁₉H₂₈ClNO₆
• Couleur/Forme: White To Light Yellow
• InChI: InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
• Code InChI: InChIKey=MSHZHSPISPJWHW-PVDLLORBSA-N
• SMILES: CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(=O)NC(=O)CCl)CO2