N-α-Tosyl-L-phenylalanylchloromethane

CAS : 402-71-1

Ref. TR-T686000

Informations sur le produit

• Nom: N-α-Tosyl-L-phenylalanylchloromethane
• Synonymes: N-alpha-Tosyl-L-phenylalanylchloromethane
• Marque: TRC

Description

Applications N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
References Jitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009); Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)

Propriétés chimiques

• Masse moléculaire: 351.848
• Formule: C₁₇H₁₈ClNO₃S
• Couleur/Forme: Neat
• InChI: InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1