(3a,5b,7a,12a,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid

CAS : 85552-38-1

Ref. TR-T887915

Informations sur le produit

• Nom: (3a,5b,7a,12a,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid
• Synonymes: alpha,7alpha,12alpha-Trihydroxy-27-nor-5beta-cholestane-24-one
• Marque: TRC
• Description: Applications (3α,5β,7α,12α,24E)-3,7,12-Trihydroxy-cholest-24-en-26-oic Acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)

Propriétés chimiques

• Masse moléculaire: 448.64
• Formule: C₂₇H₄₄O₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C27H44O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h7,15,17-24,28-30H,5-6,8-14H2,1-4H3,(H,31,32)/b16-7+/t15-,17+,18-,19-,20?,21?,22-,23+,24?,26+,27-/m1/s1
• Code InChI: InChIKey=VXQOOUCCLSSSSV-VGGRVXTFSA-N
• SMILES: C/C(=C\CC[C@@H](C)[C@H]1CCC2C3C(C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O