3-(N-1-Trityl-imidazol-4-yl)propionic Acid

CAS : 160446-35-5

Ref. TR-T888590

Informations sur le produit

• Nom: 3-(N-1-Trityl-imidazol-4-yl)propionic Acid
• Synonymes: N-1-Trityl-deamino-histidine (3-(N-1-Trityl-imidazol-4-yl)propionic acid N-1-Trityl-dihydrourocanic Acid, 1-(Triphenylmethyl)-1H-imidazole-4-propanoic Acid, Deamino-His(Trt)-OH, 3-(1-Tritylimidazol-4-yl)propionic Acid, 1-(Triphenylmethyl)-1H-imidazole-4-propanoic acid, 1H-Imidazole-4-propanoic acid, 1-(triphenylmethyl)-, 3-(1-Trityl-1H-imidazol-4-yl)propanoic acid, 3-(1-Trityl-1H-imidazol-4-yl)propionic acid, 3-(1-Tritylimidazol-4-yl)propionic acid, 3-(N-1-Trityl-Imidazol-4-Yl)Propionic Acid
• CAS: 160446-35-5

Description

Applications 3-(N-1-Trityl-imidazol-4-yl)propionic Acid is an intermediate used to prepare imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase. It is also used in the synthesis of nonracemic arylpiperazinone analogs of the carboxyl-terminal CAAL sequence of protein geranylgeranyltransferase-I (PGGTase-I) as selective inhibitors of PGGTase-I and of protein farnesyltransferase.
References Ding, C., et al.: J. Med. Chem., 42, 5241 (1999); Peng, H., et al.: Org. BIomol. Chem., 4, 1768 (2006)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 382.45
• Formule: C₂₅H₂₂N₂O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C25H22N2O2/c28-24(29)17-16-23-18-27(19-26-23)25(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-15,18-19H,16-17H2,(H,28,29)
• Code InChI: InChIKey=WPUNOGRJNPUUQT-UHFFFAOYSA-N
• SMILES: O=C(O)CCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1