VX 745

CAS : 209410-46-8

Ref. TR-V900500

Informations sur le produit

• Nom: VX 745
• Synonymes: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, 6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-, Neflamapimod, Vd 31745, Vrt 031745, Vx-745
• CAS: 209410-46-8

Description

Applications VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
References Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 436.26
• Formule: C₁₉H₉Cl₂F₂N₃OS
• Couleur/Forme: Neat
• InChI: InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
• Code InChI: InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N
• SMILES: O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl